Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase β Haploinsufficient Mice
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چکیده
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منابع مشابه
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice.
Aging and DNA polymerase beta deficiency (beta-pol(+/-)) interact to accelerate the development of malignant lymphomas and adenocarcinoma and increase tumor bearing load in mice. Folate deficiency (FD) has been shown to induce DNA damage repaired via the base excision repair (BER) pathway. We anticipated that FD and BER deficiency would interact to accelerate aberrant crypt foci (ACF) formation...
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